Blue Marble

Cancer Patients Warned Not to Self-Medicate with Chemotherapy

| Thu Mar. 29, 2007 8:07 PM PDT

A bizarre black market is forming around a simple laboratory chemical that cancer patients have pinned their last hopes for survival on. In January, New Scientist reported a discovery that sounded "too good to be true."

A Canadian researcher at the University of Alberta in Edmonton, Canada, tested dichloroacetic acid on human cells cultured outside the body and found it killed lung, breast and brain cancer cells, but not healthy cells. "Tumours in rats deliberately infected with human cancer also shrank drastically when they were fed DCA-laced water for several weeks," wrote Andy Coghlan.

But because the chemical is not patentable, Coghlan wrote, no incentive existed for pharmaceuticals to run the clinical trials necessary to make DCA legal as a cancer treatment. Soon two Web sites sprung up: one with the research papers and chat rooms to discuss DCA, and another site selling DCA supposedly for use in pets with terminal cancer. Both sites are run by a California man who operates a pest-control company. But both sites are under criminal investigation by the FDA, because DCA hasn't gone through clinical trials or been approved for human use. Even marketing DCA for pets is illegal.

Still, Evangelos Michelakis and his Canadian team, who made the discovery, have fielded thousands of emails and calls from people asking how much DCA to take. Michelakis tells New Scientist, "We're now getting emails from people asking for dosage information for, say, a 150-pound golden retriever."

But even Michelakis is warning the desperate people not to take DCA. And so are other doctors, even though at least one doctor with cancer is taking it. Michelakis fears that if anyone dies while taking DCA unsupervised, funding for clinical trials will disappear. He tells New Scientist, "We are trying to do this the right way, by putting it into clinical trials, and these websites could destroy all of this."

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Spate of Tornadoes

| Thu Mar. 29, 2007 1:32 PM PDT

tornado.jpgTime reports that "65 tornadoes were reported in Oklahoma, Texas, Kansas, Colorado and Nebraska on Wednesday." As part of my weird weather watch, I looked into these and learned that they're only sorta weird. It's tornado season, and although Colorado technically falls outside "Tornado Alley," it does see twisters pretty regularly. A National Weather Service representative told me the "number of tornadoes was large," calling the "outbreak" "significant but not of record proportions."

The Unsinkable John Lott Vs. "Freaky" Economics

| Thu Mar. 29, 2007 10:49 AM PDT
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The world of economics is predictably unpredictable; we know that markets will ebb and flow, but not when or often why. So too it goes with John Lott, the undefatigable conservative economist who is guaranteed to pop up in some new controversy of his own creation every so often. What keeps him going—and why places like AEI embrace him—remains a mystery. Lott is most infamous for his claims that crime rates are inversely proportional to rates of gun ownership; or as his book title put it, More Guns, Less Crime. Small problem: His research is far from bulletproof, and he's been repeatedly exposed and denounced for what could be charitably called sloppy research. In his defense, Lott has blamed "coding errors," claimed that some of his data have been destroyed, and in his finest moment, created a fictitious online identity to take on his critics. But none of this has slowed him down. For a good rundown of Lott's sins, see Chris Mooney's 2003 piece on our website, which shot some more holes into his work. More recently, Lott sued the Freakonomics guys for defamation after they wrote that he had "falsified his results." A judge threw part of his case out. Now Lott's firing back with a new book, Freedomnomics, a defense of the free market against "freaky theories," printed by renowned academic publisher Regnery. Fact checkers, statisticians, and economists, start your BS detectors...

Read Fortune Not Working Mother

| Wed Mar. 28, 2007 5:47 PM PDT

With all the greenwash these days, how would you go about picking the ten greenest corporations? Fortune's team of reporters started by soliciting 100 "nominations from environmentalists and consultants who have worked in the trenches of corporate America," according to the magazine. Sounds like a given. But other magazines actually run lists of best companies based on self-reported data and advertising dollars.

Most notoriously, Working Mother has named Union Pacific five times one of the best places for women to work, even though it pays for employees' Viagra and Rogaine but not contraceptives. The UP flack's spin is, "We are thrilled that Working Mother has recognized our efforts to create a culture that helps employees balance work and families." Working Mother also includes firms facing class-action suits for sex harassment. And it has named Allstate, American Express, and General Mills among the 8 best firms for women of color. But at each, 30% of new hourly hires are women of color, but 0% of newly hired executives are.

Distinguishing hype from hope in green business was a focus of Mother Jones' November issue. We reported BP's blundered but well-publicized attempt to go "Beyond Petroleum" and the near-religious conversion of a carpet industry captain.

Now for the names. Drum roll please. Fortune's "Ten Green Giants" are Honda, Continental Airlines, Tesco, PG&E, S.C. Johnson, Goldman Sachs, Swiss Re, Hewlett-Packard, Alcan, and Suncor. Any objections?

"Viagra for Women" on the British Market

| Wed Mar. 28, 2007 5:09 PM PDT

A testosterone patch to increase the female sex drive went on the market this week in the UK. Intrinsa can be prescribed only to women who have had menopause or hysterectomies. Unlike Viagra, Intrinsa takes up to a few weeks to take effect. Intrinsa targets Female Sexual Dysfunction, which was only seven years ago officially recognized as a disorder.The UK's Daily Mail predicts that Intrinsa will become a "lifestyle drug." Salon worries Intrinsa will set up unreasonable expectations for the female libido. And I think that since the roots of Female Sexual Dysfunction are often social, not physiological, a designer drug may not be the best fix.

—Rose Miller

Paper or Potato?

| Wed Mar. 28, 2007 10:48 AM PDT

Mother Jones' hometown, San Francisco, yesterday became the first U.S. city to ban non-recyclable plastic bags from use in retail stores. Not only do conventional plastic bags take up space in landfills—1,400 tons in San Francisco alone—they also require petroleum for their manufacture. City supervisor Ross Mirkarimi said, "We can't sleepwalk into the future. The end of the era of cheap oil is here."

Bags made from biodegradable materials such as potato starch are actually stronger than plastic bags, but cost more to produce.

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Environmental Fact of the Day

| Wed Mar. 28, 2007 9:21 AM PDT

A gallon of gasoline puts 19 pounds of carbon dioxide into the atmosphere. In California, passenger vehicles account for 40 percent of all greenhouse gas emissions.

Mass transit: A (relatively) easy way to limit your contribution to global warming.

Weird Weather Watch: WTF?

| Wed Mar. 28, 2007 8:38 AM PDT

Tuesday "dawned clear and breezy" in Southern California, but by the end of the day the area had experienced downpours, hail, snow, and 40-mph winds (that's powerful by most standards but outrageous for Los Angelenos). 185,000 homes lost power. The creepiest thing of all is that an Orange County Fire Authority building had its roof torn off, although erratic weather like this are increasing the area's vulnerability to fire.

Common Fungicide Causes Changes in Mating Behavior Generations After Exposure

| Tue Mar. 27, 2007 8:43 PM PDT

Female rats avoid males whose great-grandfathers were exposed to a common fruit crop fungicide. Researchers from the University of Texas at Austin examined rats whose great-grandparents were exposed to the fungicide vinclozolin, which causes early onset of cancer and kidney disease in males.

Female rats can tell the difference between male descendants of rats that have or have not been exposed to vinclozolin, and strongly prefer males descended from unexposed rats. Proving for the first time that environmental contamination affects evolution through changes in mating behavior.

Vinclozolin causes changes in the male rats' germline cells, like sperm. It doesn't directly alter DNA, instead causing changes in elements that regulate DNA. This is known as an epigenetic change.

Early onset of disease caused by initial exposure to vinclozolin is passed down generation to generation through the germline of the males. The female rats can sense something is wrong, even though they can't see it. Since males move beyond their birth territory when they mature, they carry their unlovable and fatal defects with them.

Hmm. Is the biosphere cannily healing itself, one little rat at a time? Or are rats truly destined to inherit the Earth? --Julia Whitty

Disappearing Climate Zones Mean Disappearing Species

| Tue Mar. 27, 2007 8:05 PM PDT

A new study forecasts the complete disappearance of existing climates in tropical highlands and regions near the poles. Meanwhile large swaths of the tropics and subtropics will likely develop new climates unlike any seen today, according to the National Science Foundation. Researchers at the University of Wisconsin-Madison and the University of Wyoming predict that existing climate zones will shift toward higher latitudes and higher elevations, squeezing out the climates at the extremes. In fact a lot of this is already underway, as species are already moving to higher latitudes and higher elevations to escape the heat.

The most severely affected parts of the world span heavily populated regions, including the southeastern U.S., southeastern Asia, parts of Africa. Known hotspots of biodiversity, including the Amazonian rainforest and African and South American mountain ranges will also experience radical change. Disappearing climates will affect biodiversity, increasing extinctions too.

The study's authors foresee the appearance of never-before-seen climate zones on up to 39 percent of the world's land surface area by 2100, and the global disappearance of up to 48 percent of current land climates, if current rates of carbon dioxide and other greenhouse gas emissions continue. Julia Whitty