Of all the enemies American soldiers confronted during World War II, malaria proved to be among the most stubborn. The mosquito-borne disease was a constant scourge for GIs stationed in the Pacific and Mediterranean theaters. General MacArthur's retreat to the malarial Philippine peninsula of Bataan in early 1942 led directly to his sickly army's surrender to the Japanese a few months later. The illness continued to cripple American forces during the ensuing campaigns in Papua New Guinea and Guadalcanal, where it was so rampant that a division commander ordered that no Marine be excused from duty without a temperature of at least 103°F.
Troops in Southern Europe faced similar problems. During the Seventh Army's Sicilian campaign from July to September 1943, 21,482 soldiers were admitted to the hospital for malaria; 17,535 were admitted for battle casualties. All in all, malaria accounted for almost a half-million hospital admissions and more than 300 American deaths during the war.
After some fits and starts, the military responded to the malaria outbreak with a full-out assault. The Army's Medical Department dispatched malaria control units to war zones to clear and clean standing water and bombard malarial areas with recently developed insecticides like DDT and "bug bombs." With access to quinine cut off by the Japanese conquest of Java, the government sped up trials of the anti-malarial medicine atabrine. Despite side effects such as turning the skin yellow, millions of tablets of the drug were distributed to troops toward the end of the war.
The military also warned soldiers about the dangers of the disease with an aggressive propaganda campaign that tried a variety of approaches, including patriotic appeals, racist caricatures, scare tactics, and goofy cartoons (including one drawn by the young Dr. Seuss). The campaign worked: Infection rates fell dramatically, and a healthier fighting force went on to claim victory in Europe and Asia.