Common Antidepressants Associated With Lower Bone Density


Some antidepressants appear to be associated with an increased rate of bone loss in older men and women. These SSRIs (selective serotonin reuptake inhibitors), such as Prozac, Zoloft, and Paxil, treat depression by inhibiting the protein that transports serotonin, a neurotransmitter involved in sleep and depression, reports the Journal of the American Medical Association (JAMA) via Science Daily. But serotonin may also be associated with an increased rate of bone loss in older men and women, according to two new JAMA articles. And some data suggest that SSRIs may interfere with the function of osteoclasts and osteoblasts, the cells responsible for the regular breaking down and rebuilding of bone in the body. . . So, there’s a choice for you. Depression or broken bones or both. How about looking for the root cause of the depression, not just the (dubious) chemistry? –JULIA WHITTY

  • Julia Whitty is the environmental correspondent for Mother Jones. Her latest book is Deep Blue Home: An Intimate Ecology of Our Wild Ocean. For more of her stories, click here.

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