Common Antidepressants Associated With Lower Bone Density


Some antidepressants appear to be associated with an increased rate of bone loss in older men and women. These SSRIs (selective serotonin reuptake inhibitors), such as Prozac, Zoloft, and Paxil, treat depression by inhibiting the protein that transports serotonin, a neurotransmitter involved in sleep and depression, reports the Journal of the American Medical Association (JAMA) via Science Daily. But serotonin may also be associated with an increased rate of bone loss in older men and women, according to two new JAMA articles. And some data suggest that SSRIs may interfere with the function of osteoclasts and osteoblasts, the cells responsible for the regular breaking down and rebuilding of bone in the body. . . So, there’s a choice for you. Depression or broken bones or both. How about looking for the root cause of the depression, not just the (dubious) chemistry? –JULIA WHITTY

FACT:

Mother Jones was founded as a nonprofit in 1976 because we knew corporations and the wealthy wouldn't fund the type of hard-hitting journalism we set out to do.

Today, reader support makes up about two-thirds of our budget, allows us to dig deep on stories that matter, and lets us keep our reporting free for everyone. If you value what you get from Mother Jones, please join us with a tax-deductible donation today so we can keep on doing the type of journalism 2019 demands.

We Recommend

Latest

Sign up for our newsletters

Subscribe and we'll send Mother Jones straight to your inbox.

Get our award-winning magazine

Save big on a full year of investigations, ideas, and insights.

Subscribe

Support our journalism

Help Mother Jones' reporters dig deep with a tax-deductible donation.

Donate

We have a new comment system! We are now using Coral, from Vox Media, for comments on all new articles. We'd love your feedback.