African-Americans Genetically Prone to HIV, AIDS

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New research shows that Africans and African-Americans bear a gene variant that helps protect them from malaria, but also makes them more vulnerable to HIV infection. The variant increases susceptability to HIV by 40 percent, says the San Francisco Chronicle.

The genetic trait is found in 90 percent of Africans and 60 percent of African-Americans. Thus far, it has protected against malaria by disabling a protein that some strains of malaria use to enter red blood cells. However, that same protein that’s disabled in Africans to prevent malaria can actually protect against HIV by soaking up virus cells before they can invade white blood cells. With this sponge-like protein disabled, Africans lose a key pre-infection barrier.

This finding helps explain, in part, the high HIV infection rates among Sub-Saharan Africans and Americans of African descent. On the flipside, there is a genetic variant among people of Northern European heritage that actually makes them immune to HIV infection. Scientists think the mutation was passed down by ancestors who survived the Black Plague. In one test, a man’s blood was exposed to 3,000 times the amount of HIV needed to infect a cell, but infection still didn’t occur. The HIV virus simply had no gateway of entry.

Both the European and African genetic traits are currently being studied to see if they can shed light on a cure to HIV.

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You expect the big picture, and it's our job at Mother Jones to give it to you. And right now, so many of the troubles we face are the making not of a virus, but of the quest for profit, political or economic (and not just from the man in the White House who could have offered leadership and comfort but instead gave us bleach).

In "News Is Just Like Waste Management," we unpack what the coronavirus crisis has meant for journalism, including Mother Jones’, and how we can rise to the challenge. If you're able to, this is a critical moment to support our nonprofit journalism with a donation: We've scoured our budget and made the cuts we can without impairing our mission, and we hope to raise $400,000 from our community of online readers to help keep our big reporting projects going because this extraordinary pandemic-plus-election year is no time to pull back.

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