This natural process was designed to optimize metabolism and promote the storage of body fat. And this was useful when food was hard to come by and we had to work physically hard to get it.
Now it backfires on us in the form of fat.
Ghrelin—the hunger hormone—is believed to accumulate during periods of fasting and is found in the body in high concentrations just before meals. It’s activated by a fatty acid added by an enzyme called GOAT. Originally it was assumed that the fatty acids attached to ghrelin by GOAT were produced by the body during fasting.
Exposed to fatty foods, mice with more GOAT gain more fat. Mice without GOAT gain less fat since their brain never receives the signal to store the fat.