Wow. Our experiment is off to a great start—let's see if we can finish it off sooner than expected.
At least in mice. So far. Nature reports on research presented at the annual meeting of the Society for Neuroscience. Mice fed on a high-fat diet during pregnancy and lactation had larger-than-normal offspring. Those offspring also went on to have larger-than-normal offspring.
The 1st-generation offspring also tended to overeat, whether they were fed a high-fat or normal diet. Plus they were insulin-insensitive, a feature of diabetes that often leads to obesity. The 2nd-generation offspring did not overeat, but were large and insulin-insensitive too. Male pups born to mothers on a high-fat diet also transmitted the traits to their own offspring.
The U of Pennsylvania team wants to know which genes were involved in passing on these traits. So far they've found epigenetic changes in the hypothalamus, which controls feeding behaviour. Epigenetic changes are biochemical modifications that affect how DNA functions without actually altering its nucleotide sequence. Epigenetic changes can be induced by environmental and/or genetic factors.