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Common Antidepressants Associated With Lower Bone Density

Some antidepressants appear to be associated with an increased rate of bone loss in older men and women. These SSRIs (selective serotonin reuptake inhibitors), such as Prozac, Zoloft, and Paxil, treat depression by inhibiting the protein that transports serotonin, a neurotransmitter involved in sleep and depression, reports the Journal of the American Medical Association (JAMA) via Science Daily. But serotonin may also be associated with an increased rate of bone loss in older men and women, according to two new JAMA articles. And some data suggest that SSRIs may interfere with the function of osteoclasts and osteoblasts, the cells responsible for the regular breaking down and rebuilding of bone in the body. . . So, there's a choice for you. Depression or broken bones or both. How about looking for the root cause of the depression, not just the (dubious) chemistry? --JULIA WHITTY






Comments

This is a little bit of a late response to this but sometimes the root cause of depression is an organic malfunction within the brain. I have suffered from depression since I hit puberty (36yrs old now) and trying to go without my medication (which I have desperately tried to do,via counseling, spirituality awareness and study, etc...) doesn't work. The brain is an organ like the pancreas is. And while you have some control over what goes on there, sometimes it can physically fail, like said pancreas in diabetics, and require medication to correct that failure. I agree that there are many people on anti-depressants that don't need to be and pharmaceutical treatment should be a last resort. But there are people who legitimately need them and cannot just address the source of the depression and fix it all on their own. It's a nasty problem to have because, unless you've experienced it firsthand, you can't understand what it's like to not be able to control a function of your brain. And the stigma attached to this illness, the judgement of others as to why you cannot "fix" the problem on your own, isn't helpful.

Posted by: Anonymously me on 07/03/07 at 12:47 PM  Respond

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